Advancing Safe Pregnancy Care: Microglia-Integrated Brain Organoids Usher in Better Drug Testing
A new study from the Institute of Science and Technology Austria (ISTA) introduces a brain organoid model that includes microglia, the brain’s immune cells. This addition enhances the model’s ability to simulate inflammation and improves prospects for safer pharmaceutical testing during pregnancy. The development is timely for global health and aligns with Thai prenatal care policy ambitions to refine safe medication guidelines for expectant mothers.
Historically, brain organoid models lacked microglia, limiting their accuracy in mimicking how the human brain responds to infections. By incorporating microglia, researchers can better understand how the developing nervous system reacts to infections such as Rubella, a concern for pregnant women due to potential fetal complications. In Thailand, where maternal and neonatal health remains a policy priority, this research supports national efforts to reduce congenital risks and strengthen prenatal care.