#Psychiatry

A landmark study published in Psychological Medicine has revealed that individuals suffering from major depressive disorder show signs of accelerated brain aging, offering new insights into the profound physical toll depression takes on the body. The research, which focused on a Japanese cohort, is one of the first to confirm that depression’s impact on brain structure extends beyond Western populations, emphasizing the global relevance of the findings and their implications for countries like Thailand.

A newly published study by University College London (UCL) researchers reveals that individuals who have taken antidepressants for more than two years are vastly more likely to suffer severe and long-lasting withdrawal symptoms when discontinuing the medication, compared to those prescribed antidepressants for less than six months. The findings, which come at a critical time as antidepressant prescriptions have soared worldwide, suggest that the duration of use is a key driver for withdrawal difficulty, potentially prompting a significant shift in how these medications are prescribed and managed both globally and in Thailand.

Recent findings from University College London show that people on antidepressants for more than two years are far more likely to experience severe and lasting withdrawal when stopping the medication than those who used them for under six months. With antidepressant prescriptions rising worldwide, the study suggests the duration of use strongly drives withdrawal difficulty and could influence prescribing and tapering practices in Thailand.

In Thailand, antidepressants such as SSRIs are commonly prescribed for depression and anxiety, reflecting international trends. Data from the UCL study indicate that long-term users have a tenfold higher risk of withdrawal compared with short-term users, and about one in four people who have taken antidepressants for more than two years report severe withdrawal symptoms. The growing acceptance of mental health treatment in Thai communities after the pandemic makes these findings highly relevant for patients and clinicians.

For many, the phrase “obsessive-compulsive disorder” (OCD) conjures up images of endless hand-washing, relentless checking of locked doors, or carefully lining up items in perfect order. But fresh research and expert voices now highlight unexpected symptoms often overlooked—not just by the public, but even by those who struggle with the disorder themselves. As understanding of OCD advances, mental health professionals urge a shift away from stereotypes, offering new hope for more accurate diagnosis and effective support, especially for Thai people whose experiences may take unique cultural forms (NYT).

Scientists have achieved a significant breakthrough in unraveling the brain’s mechanics behind emotional connections, an advance that holds promise for understanding—and perhaps treating—conditions such as anxiety and trauma-related disorders. In a recent study published in Nature, researchers from the RIKEN Center for Brain Science in Tokyo have identified specific brain processes enabling the formation of complex emotional associations, challenging long-standing assumptions about how human and animal brains process emotionally charged experiences (Ars Technica).

A fresh wave of research and expert voices is reshaping how Obsessive-Compulsive Disorder (OCD) is understood in Thailand. Beyond the familiar image of endless cleaning and door-checking, clinicians highlight diverse, often invisible symptoms that affect daily life. Thai mental health professionals urge moving past stereotypes to improve diagnosis and support for sufferers, with attention to how culture shapes experiences.

Historically, OCD has been portrayed through visible rituals focused on cleanliness and order. New clinical insights show a broader spectrum: persistent thoughts about harming loved ones, doubts about relationships, acute fear of mistakes, and worries about taboo subjects. Leading OCD specialists note many patients conceal their struggles, fearing their thoughts reveal something dangerous. Yet these themes are recognized as classic, though misunderstood, manifestations of the disorder.

A recent study in the Journal of Positive Psychology links optimism to better responses to SSRI antidepressants, a cornerstone treatment for major depressive disorder. The research suggests that more optimistic individuals are likelier to improve on these medications, and that growing optimism during treatment further increases recovery chances. The findings point to new avenues for mental health care in Thailand and beyond.

In Thai society, where depression remains a hidden burden, these results are particularly relevant. Depression contributes significantly to disability, and cultural factors can hinder help-seeking and adherence to long-term treatment. SSRIs are widely prescribed by mental health professionals across the country, yet responses vary. Understanding the role of optimism could help clinicians tailor care more effectively.

A recent study published in the Journal of Positive Psychology has uncovered a striking link between optimism and the likelihood of responding positively to selective serotonin reuptake inhibitors (SSRIs), a mainstay medication for major depressive disorder. The research suggests that individuals with a more optimistic outlook are not only better positioned to benefit from these antidepressants, but that increases in optimism during treatment also significantly raise the chances of recovery—a finding with important implications for the future of mental health care in Thailand and globally (PsyPost).

Recent research is challenging the long-held stereotypes of obsessive-compulsive disorder (OCD), showing that the condition goes far beyond the familiar images of repetitive hand-washing or checking light switches. A recent feature in The New York Times presented the latest scientific understanding of the disorder, highlighting that many people with OCD actually experience a broad spectrum of symptoms—often unrecognized, even by those affected—ranging from persistent doubts about relationships to distressing intrusive thoughts and moral fixations (nytimes.com).

A sweeping new analysis published in May 2025 challenges the long-standing belief that mental disorders are largely inherited. The research argues that heritability explains far less of mental illness than once thought, urging a broader view that includes environment, trauma, and social factors in mental health. This shift has important implications for Thai readers, where openness about mental health is increasing but stigma and misinformation still linger.

In Thailand, where public dialogue around mental health is expanding, it is vital to understand that conditions like depression, anxiety, or schizophrenia are not determined solely by family history. Recognizing the role of social determinants can inform better policy, more inclusive services, and clearer messaging that reduces stigma across communities.

The assumption that mental disorders are largely inherited from our parents—a bedrock belief of biological psychiatry for decades—is now under serious scrutiny. According to a detailed new analysis published in May 2025, current research demonstrates that heritability explains far less about mental illness than previously assumed, prompting renewed calls for a broader understanding of the interplay between genes, environment, and psychology in shaping mental health (Madin America).

Why does this matter for Thai readers? In a country where mental health awareness is only now gaining national attention, public discourse often echoes global trends in medicine and psychiatry, including an emphasis on genetic causation. Many Thais, especially in urban areas, may be told that conditions like depression, anxiety, or schizophrenia run in families and are predominantly genetic. Understanding that mental disorders stem from more than just DNA could help counter stigma, inform policy, and inspire more comprehensive mental health support across the country.

Recent research challenges the stereotype of obsessive-compulsive disorder as simply about hand-washing or neatness. A feature in The New York Times explains that OCD spans a wide range of symptoms many people may not recognize, including doubts about relationships, intrusive thoughts, and moral concerns. In Thailand, where public discussions of mental health are still evolving, understanding these lesser-known manifestations can reduce stigma and encourage timely care.

OCD is characterized by obsessions—unwanted thoughts, images, or urges—and compulsions, repetitive actions done to ease distress. While classic examples remain common, clinicians are noting variants such as relationship OCD, sexual-orientation concerns, and emotional contamination OCD. These aren’t separate diagnoses, but different expressions of the same condition that can disrupt daily life.

Receiving the right psychiatric diagnosis can be life-changing, yet for many sufferers of obsessive-compulsive disorder (OCD), this clarity comes years after symptoms first appear. Recent revelations and mounting research highlight the widespread misdiagnosis of OCD as general anxiety disorder—a trend that has profound consequences for mental health treatment across the globe, including in Thailand.

The latest publicised case is recounted by a UK health reporter whose experiences echo the challenges many OCD patients face. For years, the journalist’s persistent, distressing intrusive thoughts were brushed aside as “just anxiety” by doctors and therapists. Only after seeking specialist help, and on the advice of an OCD-trained psychologist, did she receive an accurate diagnosis—a development that she described as “life-changing” (Daily Mail).

Misdiagnosis of obsessive-compulsive disorder (OCD) as general anxiety is more common than many expect, and it carries heavy consequences for treatment and quality of life. Recent international findings and lived experiences point to a global pattern that also affects Thailand’s mental health landscape.

A recent public account from the UK illustrates how a patient’s intrusive thoughts were mistaken for everyday anxiety for years. After seeking specialised help and receiving an OCD-focused evaluation, she described the diagnosis as life-changing. This case underscores a pattern seen worldwide: many OCD sufferers are left without accurate treatment for far too long.

A new wave of research and personal testimony is drawing urgent attention to “high-functioning depression” — a form of depressive illness where sufferers maintain outward productivity while battling hidden internal distress. Unlike classic depression, which is often marked by withdrawal or inability to function, high-functioning depression stays masked beneath impressive academic, professional, or social achievement. The latest findings and expert recommendations, popularized in new media and books, reveal both the signs to watch for and actionable steps to escape this insidious cycle. This emerging understanding is vital for Thai society, where high performance and social harmony are deeply valued, increasing the risk that invisible suffering goes undetected.

A growing body of research and personal stories reveals a quiet form of depression that can affect high achievers: high-functioning depression. People live with inner distress while maintaining productivity and outward success. In Thailand, where performance and harmony are highly valued in workplaces, campuses, and families, this condition can easily go unnoticed.

For Thai readers in demanding roles, the issue hits close to home. A respected U.S. psychiatrist notes that success and public recognition can mask deep sadness. Thai culture’s emphasis on face-saving and collectivism can also discourage people from showing vulnerability. Understanding these dynamics helps communities spot hidden distress before it worsens.

A new review has shed light on why people living with obsessive-compulsive spectrum disorders (OCSDs), chronic tic disorders (CTDs), and attention-deficit/hyperactivity disorder (ADHD) often experience pronounced sleep disturbances—as well as how these intertwined problems could one day be better managed. The research, recently published in the Harvard Review of Psychiatry and summarised by several neuroscience outlets, finds that disruptions in a crucial brain circuit, the cortico-striatal-thalamo-cortical (CSTC) pathway, underpin both the psychiatric symptoms and the insomnia, delayed sleep onset, and other sleep issues reported in these populationsNeuroscience News.

A new review explains why people with obsessive-compulsive spectrum disorders (OCSDs), chronic tic disorders (CTDs), and ADHD often suffer from sleep disturbances, and how these issues might be better managed in the future. The study, highlighted by neuroscience outlets and summarized in academic journals, points to disruptions in a brain network called the cortico-striatal-thalamo-cortical (CSTC) circuit as the underlying mechanism for both psychiatric symptoms and insomnia, delayed sleep onset, and related sleep problems.

A new study from the University of Michigan indicates that a single dose of a novel psychedelic compound can produce weeks-long improvements in brain flexibility. The finding could open doors to innovative treatments for depression, PTSD, and neurodegenerative conditions. In experiments with laboratory mice, researchers observed not only short-term behavioral changes but also sustained cognitive enhancements, suggesting a potential shift in how these substances might support long-term brain health. Research by a leading U.S. university is now informing global discussions on neuroplasticity and mental wellbeing.

A groundbreaking new study from the University of Michigan has found that a single dose of a novel psychedelic compound can produce weeks-long improvements in brain flexibility—a finding that could pave the way for innovative therapies targeting depression, PTSD, and neurodegenerative diseases. Using advanced research techniques on laboratory mice, scientists observed that the psychedelic 25CN-NBOH not only changed behavior in the short term but led to sustained cognitive enhancements, suggesting a fundamental shift in our understanding of how these substances might promote long-term brain health (Neuroscience News).

A wave of new research is prompting Thai psychiatrists and families to reconsider long-held beliefs about psychosis. Scientists are refining how we distinguish substance-induced psychosis from primary psychotic disorders, with implications for diagnosis, treatment, and hope for patients across Thailand.

Psychosis, a condition marked by a break from reality through hallucinations or delusions, has traditionally been split into two categories: primary psychosis, intrinsic to a psychiatric illness such as schizophrenia, and substance-induced psychosis, triggered by drugs or alcohol. Clear differentiation matters for care decisions, but until now gaps in understanding have complicated clinical judgments and family planning.

A wave of fresh research is prompting Thai psychiatrists and families to reconsider long-held assumptions about psychosis, as scientists explore the crucial differences between substance-induced and primary psychotic disorders. This emerging body of evidence, highlighted in a recent Medscape report, could help guide better diagnosis, tailored treatment, and more hopeful outcomes for patients across Thailand.

Psychosis, a condition marked by a loss of contact with reality—often via hallucinations or delusions—has long been categorized into those primarily caused by a psychiatric illness, like schizophrenia, and others triggered by substance use, such as methamphetamine (“ya ba”) or cannabis. Understanding whether symptoms are “primary” (intrinsic to psychiatric illness) or “substance-induced” (caused by drug or alcohol use) shapes every aspect of medical care, but until now, the true distinctions have often been blurred, fueling debates among clinicians and researchers worldwide.

The latest in-depth investigations by international psychiatrists and psychologists are prompting a global rethink over the widespread use and perceived efficacy of antidepressants, especially in the United States, where such medications have become almost ubiquitous for treating depression, anxiety, and insomnia. New findings sharply question the central assumptions about how these drugs work, their long-term benefits, and the risks they carry—a discussion that resonates far beyond America’s borders, including in Thailand, as local mental health practices continue to evolve.

A wave of international research is prompting a global rethinking of how antidepressants are prescribed, especially in the United States where these drugs are widely used to treat depression, anxiety, and sleep problems. New findings challenge long-held beliefs about how these medications work, their long-term benefits, and their risks. The implications extend beyond the U.S., influencing mental health practices in Thailand as local care evolves.

In recent years, antidepressants moved from tightly controlled clinical tools to commonly endorsed remedies. Guidelines in some parts of the United States often recommend antidepressants as a first-line treatment for mild to moderate depression, a stance that contrasts with guidance from global health authorities and Thai care providers who emphasize caution for milder cases. The Covid-19 era saw a surge in prescriptions, underscoring a strong reliance on these medications within American health systems.