#Schizophrenia

Scientists have uncovered a surprisingly simple mechanism in the human brain that may act as a natural “dial” to help us tell the difference between what we imagine and what we perceive as real. The new study, published in Neuron on June 5, shines a light on fundamental brain processes that distinguish fact from fiction—a discovery with profound implications for understanding mental health conditions like schizophrenia, where this boundary can blur dangerously (Live Science).

In a pioneering new study, neuroscientists have traced the precise brain mechanisms that empower us to tell the difference between what we imagine and what we actually see—an ability fundamental to understanding our own experience and, when disrupted, central to psychiatric conditions like schizophrenia. The research, published this month in Neuron by a team at University College London (UCL), pinpoints the fusiform gyrus—a visual processing region of the brain—as a critical player in this reality-imagination divide, offering profound implications for mental health, technology, and our understanding of human perception (Neuroscience News).

A wave of fresh research is prompting Thai psychiatrists and families to reconsider long-held assumptions about psychosis, as scientists explore the crucial differences between substance-induced and primary psychotic disorders. This emerging body of evidence, highlighted in a recent Medscape report, could help guide better diagnosis, tailored treatment, and more hopeful outcomes for patients across Thailand.

Psychosis, a condition marked by a loss of contact with reality—often via hallucinations or delusions—has long been categorized into those primarily caused by a psychiatric illness, like schizophrenia, and others triggered by substance use, such as methamphetamine (“ya ba”) or cannabis. Understanding whether symptoms are “primary” (intrinsic to psychiatric illness) or “substance-induced” (caused by drug or alcohol use) shapes every aspect of medical care, but until now, the true distinctions have often been blurred, fueling debates among clinicians and researchers worldwide.

In the wake of a tragic incident in Cedar Rapids, Iowa, mental health advocate Leslie Carpenter emphasizes the urgent need for appropriate mental health interventions, particularly for individuals experiencing psychosis. This call comes after the death of 18-year-old Ezekiel Baseme, who had schizophrenia. His death, linked to starvation and dehydration, led to the arrest of his three brothers on charges of involuntary manslaughter. They reportedly took measures to restrain Baseme, who was reportedly in a prolonged psychotic episode, illustrating the dire consequences when serious mental health conditions are misunderstood and mishandled.