#Senolytics

A breakthrough preclinical study has revealed that clearing “zombie cells” from spinal discs may dramatically reduce chronic low back pain, a condition that affects millions of people globally and remains common among Thais. Researchers from McGill University found that two drugs—o-Vanillin and RG-7112—can target and remove these senescent cells, leading not only to reduced pain and inflammation but even signs of tissue repair in damaged spinal discs. The findings, published in Science Advances, point to a transformative new treatment that addresses the root cause of back pain rather than just masking symptoms with painkillers or surgery source.

In a groundbreaking new study published in the journal Aging, researchers have discovered that senolytics—compounds traditionally known for their anti-aging properties—might be able to slow the progression of Alzheimer’s disease. This finding offers a glimmer of hope to the millions impacted by Alzheimer’s, particularly as Thailand sees a growth in its aging population. The study’s promising results have sparked a renewed interest in senolytics, albeit with caution from the medical community about their application.