#Serotonin2a

A new study reveals that the psychedelic compound DMT changes brain activity by requiring less energy to move between mental states. Published findings in Communications Biology offer fresh insight into how altered consciousness emerges, with potential implications for mental health research in Thailand and beyond. Research coverage from reputable outlets notes this work helps explain how rapid, transient experiences under DMT unfold.

Researchers, largely from the Penn Lifespan Informatics & Neuroimaging Center at the University of Pennsylvania, studied 20 healthy adults. Each person completed two sessions, two weeks apart: one with intravenous DMT and one with a placebo. During 28-minute sessions, researchers used functional MRI and EEG to monitor brain activity while participants described the intensity of their experiences in real time.

A groundbreaking new study reveals that the psychedelic compound N,N-dimethyltryptamine—better known as DMT—profoundly changes the brain’s activity by reducing the “control energy” needed to shift between mental states, opening a fresh window into the biological mechanisms of altered consciousness. The findings, recently published in Communications Biology, not only enhance scientific understanding of psychedelics but could hold long-term implications for mental health research in Thailand and around the world (psypost.org).

As interest in psychedelic-assisted therapies grows globally and regionally, including in Thailand’s academic and healthcare circles, this innovative research stands out for mapping the moment-to-moment changes in brain network flexibility experienced under DMT—a compound central to indigenous Amazonian practices and increasingly, to scientific study. In contrast to many other psychedelics, DMT’s extremely short duration—inducing intense hallucinations and altered states for roughly 20 minutes—provides researchers the unique opportunity to capture the entire experience in real time using advanced brain imaging tools.