#Serotoninreceptors

A European university-led study used fMRI to show that LSD alters brain connectivity in distinct ways from MDMA and d-amphetamine. The findings challenge the broad “psychedelics” label and highlight the need to analyze each drug’s specific brain effects for promising therapeutic insights.

The research scanned 25 healthy volunteers under the influence of LSD, MDMA, and d-amphetamine. All three substances disrupted communication within brain networks, but LSD uniquely impacted regions tied to self-awareness and sensory processing. This helps explain why LSD often produces profound perceptual changes and shifts in the sense of self, while MDMA and d-amphetamine yield different subjective experiences.