#Smell

Groundbreaking international research unveils the strongest scientific evidence yet that human genes and biological sex fundamentally determine how individuals experience and interpret smells, opening revolutionary possibilities for personalized medicine and deeper understanding of neurological health. The landmark study, conducted by University of Leipzig researchers and published in Nature Communications, identified ten distinct genomic regions directly connected to specific odor detection abilities, with seven representing entirely new scientific discoveries. Most remarkably, three of these genetic regions demonstrate sex-specific activation patterns influenced by hormone fluctuations, explaining why scent perception can shift dramatically during menstruation, pregnancy, and other life transitions.

A landmark international study has uncovered the strongest evidence yet that our genes—along with biological sex—shape how we experience smells, opening new possibilities for understanding brain health and personalized medicine. The research, conducted by the University of Leipzig and published on July 30, 2025, in Nature Communications, identified ten distinct regions of the human genome connected to the ability to detect specific odors. Remarkably, seven of these genetic links had never before been documented, while three regions proved sensitive to sex-specific factors such as hormones, helping explain why smell perception can shift during life events like menstruation or pregnancy.

A recently reported side effect of menopause—an acute and sometimes unbearable heightening of the sense of smell—has cast light on an under-recognised health issue affecting women globally, including in Thailand. While hot flashes, mood swings, and sleep problems are well-documented hallmarks of menopause, women are coming forward with distressing accounts of ordinary smells becoming intolerable, wreaking havoc on daily life and relationships. Medical professionals admit that the problem is little understood, and concrete solutions remain elusive, leaving many women without adequate support.

Latest scientific research is dismantling the myth that humans are “bad smellers,” revealing that our sense of smell is not only ancient but deeply intertwined with memory and emotion—a connection far richer than previously thought. This new understanding sheds light on how even a simple whiff of a familiar odor can instantly transport us back in time, evoking powerful memories and emotions, and opens the possibility of harnessing scents in therapeutic, educational, and cultural contexts in Thailand and beyond.