#StJohnsWort

A sweeping new scientific review analyzing 64 commonly used natural and over-the-counter (OTC) remedies for depression has revealed that just a few have real evidence backing their effectiveness, raising important questions for both Thai consumers and healthcare professionals seeking safe, accessible options for managing mental health. The findings, published in 2025 and featured on Science Daily, challenge widespread assumptions about the power of widely sold supplements and herbs, highlighting which products may truly help—and which may offer nothing more than hope in a bottle.

A new review of over-the-counter supplements popular among people with depression has found that while some may offer benefits—particularly for those with mild to moderate symptoms—the evidence supporting most supermarket remedies remains limited and nuanced. The findings, drawing from an assessment of 209 studies and reviewed by prominent researchers at Southern Cross University, further clarify the role of widely available vitamins, herbal products, and dietary supplements in mental health care as Thai consumers face a similarly surging marketplace for such treatments.

From yellow blooms gleaming in midsummer fields to bottles lining pharmacy shelves, St. John’s wort (Hypericum perforatum) has captured human fascination for centuries. Once considered a magical plant to ward off evil and heal the mind and body, today this humble wildflower sits at the intersection of folk medicine and rigorous clinical investigation. As health-conscious readers search for natural ways to support mental health, St. John’s wort stands as a classic example of how traditional botanical wisdom and modern science sometimes converge—and sometimes diverge—in the ongoing quest for well-being.