#StJohnsWort

A global review of 64 over-the-counter and natural remedies for depression finds only a few with solid evidence of benefit. Published in 2025, the study urges caution against aggressive marketing of supplements and provides guidance for Thai consumers and healthcare professionals seeking safe, accessible options.

Depression affects people worldwide, including Thailand, where symptoms surged after the COVID-19 era and amid ongoing economic pressures. In Thai communities, mental health stigma still leads many to try herbs or traditional medicines instead of seeking professional care. Data from international research underscore the need for reliable information on effective treatments.

A sweeping new scientific review analyzing 64 commonly used natural and over-the-counter (OTC) remedies for depression has revealed that just a few have real evidence backing their effectiveness, raising important questions for both Thai consumers and healthcare professionals seeking safe, accessible options for managing mental health. The findings, published in 2025 and featured on Science Daily, challenge widespread assumptions about the power of widely sold supplements and herbs, highlighting which products may truly help—and which may offer nothing more than hope in a bottle.

A new review of over-the-counter mood supplements helps clarify what might help for mild to moderate depression—and where evidence remains limited. The analysis examined 209 studies and was led by researchers from Southern Cross University, offering a clearer view for Thai consumers navigating a busy market of vitamins, herbs, and dietary products.

Depression is a leading cause of disability worldwide, including Thailand. Many people turn to mood boosters such as omega-3 capsules or herbal teas due to stigma around treatment, cost barriers, or hesitation about prescription medicines. In Thailand, rising health awareness and a thriving herbal-supplement scene linked to traditional medicine mirror global trends highlighted by the review.

A new review of over-the-counter supplements popular among people with depression has found that while some may offer benefits—particularly for those with mild to moderate symptoms—the evidence supporting most supermarket remedies remains limited and nuanced. The findings, drawing from an assessment of 209 studies and reviewed by prominent researchers at Southern Cross University, further clarify the role of widely available vitamins, herbal products, and dietary supplements in mental health care as Thai consumers face a similarly surging marketplace for such treatments.

St. John’s wort, a bright yellow flowering herb, has long fascinated people. Once believed to ward off evil and ease emotional distress, it now sits at the crossroads of traditional wisdom and clinical research. For health-conscious readers in Thailand, the plant offers lessons about how natural remedies can both help and harm when used with modern medicines.

This article traces its rich history, traditional uses in various cultures, current scientific evidence, and essential safety considerations for anyone curious about this herbal option.

From yellow blooms gleaming in midsummer fields to bottles lining pharmacy shelves, St. John’s wort (Hypericum perforatum) has captured human fascination for centuries. Once considered a magical plant to ward off evil and heal the mind and body, today this humble wildflower sits at the intersection of folk medicine and rigorous clinical investigation. As health-conscious readers search for natural ways to support mental health, St. John’s wort stands as a classic example of how traditional botanical wisdom and modern science sometimes converge—and sometimes diverge—in the ongoing quest for well-being.