#Synapse

A new discovery from Rutgers University shines a light on how memory forms and declines. Scientists have identified a protein called cypin that acts like a master regulator, strengthening neural connections and protecting them from aging-related damage. The study, published in Science Advances, explains how cypin interacts with the brain’s waste disposal and protein-management systems to bolster synapses—the tiny junctions where memories are made.

The finding carries particular resonance for Thailand, where dementia and cognitive disorders are increasingly challenging families and healthcare resources. As Thailand’s population ages, researchers and clinicians are seeking ways to slow memory loss and maintain independence for elderly residents. Data from Thailand’s healthcare studies and World Health Organization assessments show rising dementia rates, with hundreds of thousands of seniors potentially affected. A breakthrough like this offers scientific insight and potential avenues for future therapies that could benefit Thai families.

A team led by a Rutgers University neuroscientist has identified a surprising molecular regulator that helps keep the brain’s connections strong: a cytosolic protein called cypin. New experiments in cultured neurons and in adult mice show that cypin promotes a specific form of polyubiquitination (K63-linked ubiquitin chains) on synaptic proteins, alters proteasome composition at synapses, and increases levels of key synaptic scaffolding and glutamate receptor proteins tied to learning and memory. The findings, published in Science Advances, point to cypin as a “master key” that can tune both pre‑ and postsynaptic content and suggest it could be a target for new therapies aimed at neurodegenerative disease and recovery after traumatic brain injury (Science Advances study; Rutgers news release; SciTechDaily summary).

Deep within the microscopic architecture of the human brain, Rutgers University scientists have discovered a remarkable molecular conductor orchestrating the symphony of memory formation—a protein called cypin that acts as the brain’s own master electrician, rewiring neural connections to strengthen learning and protect against cognitive decline. This groundbreaking research, published in the prestigious journal Science Advances, reveals how cypin manipulates the brain’s cellular recycling system to fortify synapses, the critical communication bridges between neurons where memories are born and preserved, offering unprecedented hope for developing treatments against Alzheimer’s disease, Parkinson’s, and traumatic brain injuries that devastate millions of Thai families each year.